Phe_250_13-PRISM_deCODE

Sample size: 2517 cases, 445450 controls, 447967 samples

Phenotype description:Type 1 diabetes with ophthalmic manifestations

Phenotype:Endocrine or Metabolic

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PRISM models (cis + trans): UKB-PPP (Olink)deCODE (SomaScan)

BLISS models (cis): ARIC_AA ARIC_EA UKBPPP_AFR UKBPPP_EUR deCODE

PRISM, deCODE (SomaScan) × MVP. Each point is one protein: its PRISM model (cis and trans pQTL loci, pleiotropic hotspot loci excluded) tested against this phenotype's GWAS summary statistics. A positive effect means a higher genetically predicted protein level goes with a higher trait value or risk.

1,965 proteins tested (model R² ≥ 0.01 and more than 10 SNPs). 9 significant at a Benjamini–Hochberg FDR of 5%, computed over all traits of this panel × cohort scan (p ≤ 8.34e-04; dashed line). Methods and bulk downloads.

Significant proteins across the PRISM panels:

Genetic entity	Model	P-value	Effect Size (se)