Phe_250_13-PRISM_UKBPPP
Sample size: 2517 cases, 445450 controls, 447967 samples
Phenotype description:Type 1 diabetes with ophthalmic manifestations
Phenotype:Endocrine or Metabolic
PRISM models (cis + trans): UKB-PPP (Olink)deCODE (SomaScan)
BLISS models (cis): ARIC_AAARIC_EAUKBPPP_AFRUKBPPP_EURdeCODE
PRISM, UKB-PPP (Olink) × MVP. Each point is one protein: its PRISM model (cis and trans pQTL loci, pleiotropic hotspot loci excluded) tested against this phenotype's GWAS summary statistics. A positive effect means a higher genetically predicted protein level goes with a higher trait value or risk.
1,623 proteins tested (model R² ≥ 0.01 and more than 10 SNPs). 17 significant at a Benjamini–Hochberg FDR of 5%, computed over all traits of this panel × cohort scan (p ≤ 1.14e-03; dashed line). Methods and bulk downloads.
Significant proteins across the PRISM panels:
| Genetic entity | Model | P-value | Effect Size (se) |
|---|
