NSDemMed-PRISM_UKBPPP

Sample size: 2486 cases, 313182 controls, 315668 samples

Phenotype description:Takes medication for Dementia (includes Alzheimer's, Vascular, etc.)?

Phenotype:Disease Diagnosis

Download association results

PRISM models (cis + trans): UKB-PPP (Olink)deCODE (SomaScan)

BLISS models (cis): ARIC_EA UKBPPP_EUR deCODE

PRISM, UKB-PPP (Olink) × MVP. Each point is one protein: its PRISM model (cis and trans pQTL loci, pleiotropic hotspot loci excluded) tested against this phenotype's GWAS summary statistics. A positive effect means a higher genetically predicted protein level goes with a higher trait value or risk.

1,623 proteins tested (model R² ≥ 0.01 and more than 10 SNPs). 3 significant at a Benjamini–Hochberg FDR of 5%, computed over all traits of this panel × cohort scan (p ≤ 1.14e-03; dashed line). Methods and bulk downloads.

Significant proteins across the PRISM panels:

Genetic entity	Model	P-value	Effect Size (se)